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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2400908Generated: October 30, 2026

tert-butyl N-[4-(hydroxymethyl)oxan-4-yl]carbamate → (4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}tetrahydro-2H-pyran-4-yl)carbamic acid tert-butyl ester

https://huagongshe.com/reaction/2400908

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl N-[4-(hydroxymethyl)oxan-4-yl]carbamateHCID 67114425—
Reactant5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dioneHCID 86659657—
Product(4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}tetrahydro-2H-pyran-4-yl)carbamic acid tert-butyl esterHCID 86659665—

Reaction Steps

(4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}tetrahydro-2H-pyran-4-yl)carbamic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione and (4-hydroxymethyltetrahydro-2H-pyran-4-yl)carbamic acid tert-butyl ester following General Procedure J.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08796256B2
Source datasetuspto-grants-2014_08
ORD IDord-74888f5362b449b797dc89f710f9e417
Source noteuspto-grants-2014_08