Methyl chloroformate → HCID 58530517, compound

HRID 2400909Notes

Reaction equation

[NH2:1][C:2]1([CH2:8][N:9]2[C:13](=[O:14])/[C:12](=[CH:15]/[C:16]3[CH:17]=[C:18]4[C:22](=[CH:23][CH:24]=3)[N:21]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:27]=3[C:33]([F:36])([F:35])[F:34])[N:20]=[CH:19]4)/[S:11][C:10]2=[O:37])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.Cl[C:39]([O:41][CH3:42])=[O:40]>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][N:21]2[C:22]3[C:18](=[CH:17][C:16](/[CH:15]=[C:12]4/[C:13](=[O:14])[N:9]([CH2:8][C:2]5([NH:1][C:39](=[O:40])[O:41][CH3:42])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]5)[C:10](=[O:37])[S:11]/4)=[CH:24][CH:23]=3)[CH:19]=[N:20]2)=[C:27]([C:33]([F:36])([F:35])[F:34])[CH:28]=1

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 58530721HCID 58530721, compound

Product 1

HCID 58530517HCID 58530517, compound

Procedure

Methyl (4-{[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}tetrahydro-2H-pyran-4-yl)carbamate was prepared from (5Z)-3-[(4-aminotetrahydro-2H-pyran-4-yl)methyl]-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (Example 308) and methyl chloroformate following General Procedure R3.

Sources & evidence

ORD record: ord-8b69178bab7c436baae498e56954406f
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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