HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 6-Oxa-3-azabicyclo(3.1.0)hexane-3-carboxylate → 3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(trans)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 6-Oxa-3-azabicyclo(3.1.0)hexane-3-carboxylate | HCID 10103880 | — |
| Reactant | 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione | HCID 86659657 | — |
| Product | 3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(trans)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86659671 | — |
Reaction Steps
3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(trans)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione (from Example 1) and 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester following a similar procedure as described for Example 270.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796256B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7da9f96bfa3545408870b5d88a0bf489 |
| Source note | uspto-grants-2014_08 |