HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R,4R)-tert-Butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate → 3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(cis)-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R,4R)-tert-Butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate | HCID 57416936 | — |
| Reactant | 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione | HCID 86659657 | — |
| Product | 3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(cis)-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86659675 | — |
Reaction Steps
3-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(cis)-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione (from Example 1) and (trans)-3-fluoro-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester following General Procedure J.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796256B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1106a31e0fa2454f9fb5c97240dc690e |
| Source note | uspto-grants-2014_08 |