tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate → 4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-3-methyl-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(trans)-3-fluoropiperidine-1-carboxylic acid tert-butyl ester

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Reaction Steps

4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-3-methyl-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-(trans)-3-fluoropiperidine-1-carboxylic acid tert-butyl ester was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)-benzyl]-3-methyl-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 36) and (cis)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (prepared as described in U.S. Pat. Pub. No. 2007/0249589) following General Procedure J.

Provenance & Evidence