HCID 12231218, compound → HCID 86659682, compound

HRID 2400930Notes

Reaction equation

HRID 2400930 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[OH:24][CH2:25][CH2:26][N:27]1[C:31](=[O:32])[CH2:30][S:29][C:28]1=[O:33]>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:30]4/[C:31](=[O:32])[N:27]([CH2:26][CH2:25][OH:24])[C:28](=[O:33])[S:29]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:21])([F:22])[F:23])[CH:3]=1

Participants

3

Reactant 2

HCID 12231218HCID 12231218, compoundHCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 86659682HCID 86659682, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylene)-3-(2-hydroxyethyl)thiazolidine-2,4-dione was prepared from [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) and 3-(2-hydroxyethyl)thiazolidine-2,4-dione following General Procedure E.

Sources & evidence

ORD record
ord-833b7585a9f6443c83086f9ff5ad85df
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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