HCID 71437973, compound → HCID 58530488, compound

HRID 2400933Notes

Reaction equation

[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:26])[N:19]([CH2:23][CH2:24]O)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[CH3:33][O:34][C:35]([N:37]1[CH2:41][CH2:40][NH:39][S:38]1(=[O:43])=[O:42])=[O:36]>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:26])[N:19]([CH2:23][CH2:24][N:39]5[S:38](=[O:43])(=[O:42])[N:37]([C:35]([O:34][CH3:33])=[O:36])[CH2:41][CH2:40]5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1

Participants

Reactant 2

HCID 71437973HCID 71437973, compound

HCID 86659682HCID 86659682, compound

Product 1

HCID 58530488HCID 58530488, compound

Procedure

Methyl 5-{2-[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylene)-3-(2-hydroxyethyl)thiazolidine-2,4-dione (from Example 340) and 1,1-dioxo-1λ6-[1,2,5]thiadiazolidine-2-carboxylic acid methyl ester following General Procedure C.

Sources & evidence

ORD record: ord-9a49c9819c8145dfacf0e3bd9aeafbb4
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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