HCID 58530433, compound → HCID 58530580, compound

HRID 2400934Notes

Reaction equation

HRID 2400934 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23][C:24](O)=[O:25])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:33])([F:32])[F:31])[CH:3]=1.[CH3:34][O:35][C:36]([N:38]1[CH2:42][CH2:41][NH:40][S:39]1(=[O:44])=[O:43])=[O:37]>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23][C:24]([N:40]5[S:39](=[O:44])(=[O:43])[N:38]([C:36]([O:35][CH3:34])=[O:37])[CH2:42][CH2:41]5)=[O:25])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:32])([F:31])[F:33])[CH:3]=1

Participants

3

Reactant 2

HCID 58530433HCID 58530433, compoundHCID 71437973HCID 71437973, compound

Product 1

HCID 58530580HCID 58530580, compound

Procedure

Methyl 5-{[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetyl}-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid (from Example 4) and 1,1-dioxo-1λ6-[1,2,5]thiadiazolidine-2-carboxylic acid methyl ester (from Example 339) following General Procedure C.

Sources & evidence

ORD record
ord-37f1d830e2d54ab88a46bb91c80fd1e2
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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