tert-Butyl bromoacetate → HCID 58530801, compound

HRID 2400946Notes

Reaction equation

HRID 2400946 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[C:11]([F:24])[C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.Br[CH2:32][C:33]([O:35]C(C)(C)C)=[O:34]>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[C:11]([F:24])[C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:32][C:33]([OH:35])=[O:34])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:29])([F:28])[F:30])[CH:3]=1

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 86659689HCID 86659689, compound

Product 1

HCID 58530801HCID 58530801, compound

Procedure

[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine and tert-butyl bromoacetate following General Procedure I.

Sources & evidence

ORD record
ord-1c2b49066e724a5da9a64b38bf415bb7
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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