1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 58530910, compound

HRID 2400947Notes

Reaction equation

HRID 2400947 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([N:8]2[C:12](=[O:13])[CH2:11][S:10][C:9]2=[O:14])[CH2:4][CH2:3]1.[Cl:15][C:16]1[CH:33]=[CH:32][C:19]([CH2:20][N:21]2[C:29]3[C:24](=[CH:25][C:26]([CH:30]=O)=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[C:18]([C:34]([F:37])([F:36])[F:35])[CH:17]=1>>[Cl:15][C:16]1[CH:33]=[CH:32][C:19]([CH2:20][N:21]2[C:29]3[C:24](=[CH:25][C:26](/[CH:30]=[C:11]4/[C:12](=[O:13])[N:8]([N:5]5[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]5)[C:9](=[O:14])[S:10]/4)=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[C:18]([C:34]([F:35])([F:37])[F:36])[CH:17]=1

Participants

3

Reactant 2

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehydeHCID 86659690HCID 86659690, compound

Product 1

HCID 58530910HCID 58530910, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(4-methylpiperazin-1-yl)-1,3-thiazolidine-2,4-dione was prepared from 3-(4-methyl-piperazin-1-yl)-thiazolidine-2,4-dione and [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) following General Procedure E.

Sources & evidence

ORD record
ord-a5c2e8dff871467789beecab5485f8dc
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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