1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 58530666, compound

HRID 2400951Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([N:14]2[C:18](=[O:19])[CH2:17][S:16][C:15]2=[O:20])[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:21][C:22]1[CH:39]=[CH:38][C:25]([CH2:26][N:27]2[C:35]3[C:30](=[CH:31][C:32]([CH:36]=O)=[CH:33][CH:34]=3)[CH:29]=[N:28]2)=[C:24]([C:40]([F:43])([F:42])[F:41])[CH:23]=1>>[Cl:21][C:22]1[CH:39]=[CH:38][C:25]([CH2:26][N:27]2[C:35]3[C:30](=[CH:31][C:32](/[CH:36]=[C:17]4/[C:18](=[O:19])[N:14]([N:11]5[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]5)[C:15](=[O:20])[S:16]/4)=[CH:33][CH:34]=3)[CH:29]=[N:28]2)=[C:24]([C:40]([F:41])([F:43])[F:42])[CH:23]=1

Participants

Reactant 2

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

HCID 86659691HCID 86659691, compound

Product 1

HCID 58530666HCID 58530666, compound

Procedure

((5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-piperazin-1-yl-1,3-thiazolidine-2,4-dione was prepared from 4-(2,4-dioxo-thiazolidin-3-yl)piperazine-1-carboxylic acid tert-butyl ester and [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) following General Procedure F.

Sources & evidence

ORD record: ord-4446cd8892cc47198360ec7e3cb39f8a
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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