1-(4-Bromo-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde → HCID 86659697, compound

HRID 2400962Notes

Reaction equation

HRID 2400962 reaction equation
[O:1]=[C:2]1[N:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[C:5](=[O:12])[CH2:4][S:3]1.[Br:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][C:24]([CH:28]=O)=[CH:25][CH:26]=3)[CH:21]=[N:20]2)=[C:16]([C:32]([F:35])([F:34])[F:33])[CH:15]=1>>[Br:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][C:24](/[CH:28]=[C:4]4/[C:5](=[O:12])[N:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[C:2](=[O:1])[S:3]/4)=[CH:25][CH:26]=3)[CH:21]=[N:20]2)=[C:16]([C:32]([F:33])([F:35])[F:34])[CH:15]=1

Participants

3

Reactant 2

HCID 866545531-(4-Bromo-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehydeHCID 86659694N-(2,4-dioxothiazolidin-3-yl)methanesulfonamide

Product 1

HCID 86659697HCID 86659697, compound

Procedure

N-[(5Z)-5-({1-[4-Bromo-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methanesulfonamide was prepared from N-(2,4-dioxothiazolidin-3-yl)methanesulfonamide (from Example 360) and [4-bromo-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde following General Procedure E.

Sources & evidence

ORD record
ord-d72a6eb835384b00a9b01b7f228f0bec
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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