참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Selectfluor | HCID 2724933 | — |
| 반응물 | 1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde | HCID 86654547 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(4-chloro-2-trifluoromethyl-benzyl)-3-fluoro-1H-indazole-5-carbaldehyde | HCID 86659699 | — |
반응 단계
A suspension of 1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (0.9 mmol, from Example 1)) and SelectFluor® (2 eq., Aldrich) in CH3CN (3 mL) was heated in a microwave reactor at 140° C. for 30 min. The solvent was evaporated and the residue was washed with DCM. The insoluble solid was discarded. The combined organic washings were concentrated and the residue was purified by flash chromatography (0-20% EtOAc/Hex) to afford 1-[4-chloro-2-(trifluoromethyl)benzyl]-3-fluoro-1H-indazol-5-carbaldehyde.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08796256B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_08 |
|---|
| ORD ID | ord-c4f14e175b9042ee9f8c66e6293ca043 |
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| 출처 메모 | uspto-grants-2014_08 |
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