2,4-Bis(trifluoromethyl)benzyl bromide → 1-(2,4-Bis-trifluoromethyl-benzyl)-3-iodo-1H-indazole-5-carbaldehyde

HRID 2400970Notes

Reaction equation

HRID 2400970 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[O:12])[CH:9]=2)[NH:4][N:3]=1.[F:13][C:14]([F:28])([F:27])[C:15]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:16]=1[CH2:17]Br>>[F:13][C:14]([F:27])([F:28])[C:15]1[CH:22]=[C:21]([C:23]([F:26])([F:24])[F:25])[CH:20]=[CH:19][C:16]=1[CH2:17][N:4]1[C:5]2[C:10](=[CH:9][C:8]([CH:11]=[O:12])=[CH:7][CH:6]=2)[C:2]([I:1])=[N:3]1

Participants

3

Reactant 2

HCID 5188712,4-Bis(trifluoromethyl)benzyl bromideHCID 178519380HCID 178519380, compound

Product 1

HCID 866545851-(2,4-Bis-trifluoromethyl-benzyl)-3-iodo-1H-indazole-5-carbaldehyde

Procedure

1-[2,4-Bis(trifluoromethyl)benzyl]-3-iodo-1H-indazol-5-carbaldehyde was prepared from 3-iodo-1H-indazol-5-carbaldehyde (from Example 367) and 2,4-bis-(trifluoromethyl)benzyl bromide following General Procedure A.

Sources & evidence

ORD record
ord-5f3616a20b1942e29aea861a0abad3e2
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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