HCID 58530802, compound → HCID 58530726, compound

HRID 2400974Notes

Reaction equation

HRID 2400974 reaction equation
[O:1]=[C:2]1[N:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[C:5](=[O:12])[CH2:4][S:3]1.[Cl:13][C:14]1[CH:42]=[CH:41][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][C:24](/[CH:29]=C4/C(=O)N(CC(O)=O)C(=O)S/4)=[C:25]([F:28])[CH:26]=3)[CH:21]=[N:20]2)=[C:16]([C:43]([F:46])([F:45])[F:44])[CH:15]=1>>[Cl:13][C:14]1[CH:42]=[CH:41][C:17]([CH2:18][N:19]2[C:27]3[C:22](=[CH:23][C:24](/[CH:29]=[C:4]4/[C:5](=[O:12])[N:6]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[C:2](=[O:1])[S:3]/4)=[C:25]([F:28])[CH:26]=3)[CH:21]=[N:20]2)=[C:16]([C:43]([F:46])([F:45])[F:44])[CH:15]=1

Participants

3

Reactant 2

HCID 58530802HCID 58530802, compoundHCID 86659694N-(2,4-dioxothiazolidin-3-yl)methanesulfonamide

Product 1

HCID 58530726HCID 58530726, compound

Procedure

N-[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-6-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methanesulfonamide was prepared from N-(2,4-dioxothiazolidin-3-yl)methanesulfonamide (from Example 360) and [4-chloro-2-(trifluoromethyl)benzyl]-6-fluoro-1H-indazol-5-carbaldehyde (from Example 348) following General Procedure E.

Sources & evidence

ORD record
ord-b07e7a15def447fbbcd583914cdb7c09
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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