2-Butenoic acid, 4-bromo-, methyl ester → HCID 86659701, compound

HRID 2400976Notes

Reaction equation

HRID 2400976 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Br[CH2:31]/[CH:32]=[CH:33]/[C:34]([O:36][CH3:37])=[O:35]>>[CH3:37][O:36][C:34](=[O:35])/[CH:33]=[CH:32]/[CH2:31][N:19]1[C:18](=[O:23])/[C:17](=[CH:16]/[C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=2[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]3)/[S:21][C:20]1=[O:22]

Participants

3

Reactant 2

HCID 53691752-Butenoic acid, 4-bromo-, methyl esterHCID 86659608HCID 86659608, compound

Product 1

HCID 86659701HCID 86659701, compound

Procedure

(2E)-4-[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]but-2-enoic acid methyl ester was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and methyl 4-bromocrotonate following General Procedure S.

Sources & evidence

ORD record
ord-be7dd7c913224f2a9251c19ce24a5060
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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