Ethanolamine → HCID 58530477, compound

HRID 2400979Notes

Reaction equation

C[O:2][C:3](=[O:40])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[C:15](=[O:16])/[C:14](=[CH:17]/[C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[N:23]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=3[C:35]([F:38])([F:37])[F:36])[N:22]=[CH:21]4)/[S:13][C:12]2=[O:39])[CH:5]=1.C(CN)O>>[Cl:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][N:23]2[C:24]3[C:20](=[CH:19][C:18](/[CH:17]=[C:14]4/[C:15](=[O:16])[N:11]([CH2:10][C:6]5[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=5)[C:3]([OH:40])=[O:2])[C:12](=[O:39])[S:13]/4)=[CH:26][CH:25]=3)[CH:21]=[N:22]2)=[C:29]([C:35]([F:37])([F:36])[F:38])[CH:30]=1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 86659703HCID 86659703, compound

Product 1

HCID 58530477HCID 58530477, compound

Procedure

3-{[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}benzoic acid was prepared from 3-{[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}benzoic acid methyl ester following General Procedure 0 and converted to the corresponding ethanolamine salt following General Procedure T.

Sources & evidence

ORD record: ord-c46db79ddff845aaa53da9b9b3bc2546
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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