Ethanolamine → HCID 58530775, compound

HRID 2400983Notes

Reaction equation

C[O:2][C:3]([C:5]1[O:6][C:7]([CH2:10][N:11]2[C:15](=[O:16])/[C:14](=[CH:17]/[C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[N:23]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=3[C:35]([F:38])([F:37])[F:36])[N:22]=[CH:21]4)/[S:13][C:12]2=[O:39])=[CH:8][CH:9]=1)=[O:4].C(CN)O>>[Cl:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][N:23]2[C:24]3[C:20](=[CH:19][C:18](/[CH:17]=[C:14]4/[C:15](=[O:16])[N:11]([CH2:10][C:7]5[O:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][CH:8]=5)[C:12](=[O:39])[S:13]/4)=[CH:26][CH:25]=3)[CH:21]=[N:22]2)=[C:29]([C:35]([F:38])([F:37])[F:36])[CH:30]=1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 86659705HCID 86659705, compound

Product 1

HCID 58530775HCID 58530775, compound

Procedure

5-{[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}furan-2-carboxylic acid was prepared from 5-{[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}furan-2-carboxylic acid methyl ester following General Procedure 0 and converted to the corresponding ethanolamine salt following General Procedure T.

Sources & evidence

ORD record: ord-eed9c01603e2445daa8a7b81f4913842
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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