1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 86659706, compound

HRID 2400984Notes

Reaction equation

HRID 2400984 reaction equation
[O:1]=[C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][C@H:8]2[F:20])[C:5](=[O:21])[CH2:4][S:3]1.[Cl:22][C:23]1[CH:40]=[CH:39][C:26]([CH2:27][N:28]2[C:36]3[C:31](=[CH:32][C:33]([CH:37]=O)=[CH:34][CH:35]=3)[CH:30]=[N:29]2)=[C:25]([C:41]([F:44])([F:43])[F:42])[CH:24]=1>>[Cl:22][C:23]1[CH:40]=[CH:39][C:26]([CH2:27][N:28]2[C:36]3[C:31](=[CH:32][C:33](/[CH:37]=[C:4]4/[C:5](=[O:21])[N:6]([C@@H:7]5[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:9][C@H:8]5[F:20])[C:2](=[O:1])[S:3]/4)=[CH:34][CH:35]=3)[CH:30]=[N:29]2)=[C:25]([C:41]([F:42])([F:44])[F:43])[CH:24]=1

Participants

3

Reactant 2

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehydeHCID 86659643HCID 86659643, compound

Product 1

HCID 86659706HCID 86659706, compound

Procedure

1,1-Dimethylethyl trans-4-{(5Z)-5-[(1-{[4-chloro-2-(trifluoromethyl)phenyl]methyl}-1H-indazol-5-yl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}-3-fluoropiperidine-1-carboxylate was prepared either from 1,1-dimethylethyl trans-4-(2,4-dioxo-1,3-thiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate (from Example 273) and [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) following General Procedure F1, or as described in Example 273, Preparation 2.

Workup

  1. customas described in Example 273, Preparation 2

Sources & evidence

ORD record
ord-46f64cea40c14e768d045117b152a06e
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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