(Chloromethyl)sulfonyl chloride → HCID 58530921, compound

HRID 2400987Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[C:28]([F:31])([F:30])[F:29])[N:15]=[CH:14]3)/[S:6][C:5]1=[O:32].[Cl:33][CH2:34][S:35](Cl)(=[O:37])=[O:36]>>[Cl:33][CH2:34][S:35]([NH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[C:28]([F:30])([F:29])[F:31])[N:15]=[CH:14]3)/[S:6][C:5]1=[O:32])(=[O:37])=[O:36]

Participants

Reactant 2

HCID 77054(Chloromethyl)sulfonyl chloride

HCID 58530605HCID 58530605, compound

Product 1

HCID 58530921HCID 58530921, compound

Procedure

1-Chloro-N-{2-[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}-methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}methanesulfonamide was prepared from 3-(2-aminoethyl)-(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (from Example 49) and chloromethanesulfonyl chloride following General Procedure U.

Sources & evidence

ORD record: ord-c9f57a510cff4dd1861dae348c5cacfb
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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