N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol → HCID 86659707, compound

HRID 2400995Notes

Reaction equation

HRID 2400995 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.O[CH2:31][CH2:32][N:33]([CH3:41])[C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37]>>[C:36]([O:35][C:34](=[O:40])[N:33]([CH2:32][CH2:31][N:19]1[C:18](=[O:23])[C:17](=[CH:16][C:12]2[CH:11]=[C:10]3[C:15](=[CH:14][CH:13]=2)[N:7]([CH2:6][C:5]2[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=2[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]3)[S:21][C:20]1=[O:22])[CH3:41])([CH3:39])([CH3:38])[CH3:37]

Participants

3

Reactant 2

HCID 545700N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanolHCID 86659608HCID 86659608, compound

Product 1

HCID 86659707HCID 86659707, compound

Procedure

(2-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}ethyl)methylcarbamic acid tert-butyl ester was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and tert-butyl N-(2-hydroxyethyl)-N-methylcarbamate following General Procedure J.

Sources & evidence

ORD record
ord-1644f5c661994b418a64c7c2626f159f
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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