1-Pyrrolidinesulfonyl chloride → HCID 58530664, compound

HRID 2400997Notes

Reaction equation

HRID 2400997 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[N:19]([CH2:23][CH2:24][NH:25][CH3:26])[C:18]4=[O:27])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:33])([F:32])[F:31])[CH:3]=1.[N:34]1([S:39](Cl)(=[O:41])=[O:40])[CH2:38][CH2:37][CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23][CH2:24][N:25]([CH3:26])[S:39]([N:34]5[CH2:38][CH2:37][CH2:36][CH2:35]5)(=[O:41])=[O:40])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:31])([F:33])[F:32])[CH:3]=1

Participants

3

Reactant 2

HCID 64839021-Pyrrolidinesulfonyl chlorideHCID 86659708HCID 86659708, compound

Product 1

HCID 58530664HCID 58530664, compound

Procedure

N-{2-[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}-N-methylpyrrolidine-1-sulfonamide was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-3-(2-methylaminoethyl)thiazolidine-2,4-dione (from Example 394) and pyrrolidine-1-sulfonyl chloride following General Procedure U.

Sources & evidence

ORD record
ord-ab2063358a94446aae70a6cd7924be41
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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