4-Chloromethylthiazol-2-ylamine → HCID 58530403, compound

HRID 2401001Notes

Reaction equation

HRID 2401001 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Cl[CH2:31][C:32]1[N:33]=[C:34]([NH2:37])[S:35][CH:36]=1>>[NH2:37][C:34]1[S:35][CH:36]=[C:32]([CH2:31][N:19]2[C:18](=[O:23])/[C:17](=[CH:16]/[C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=3[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]4)/[S:21][C:20]2=[O:22])[N:33]=1

Participants

3

Reactant 2

HCID 732294-Chloromethylthiazol-2-ylamineHCID 86659608HCID 86659608, compound

Product 1

HCID 58530403HCID 58530403, compound

Procedure

(5Z)-3-[(2-Amino-1,3-thiazol-4-yl)methyl]-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and 4-chloromethylthiazol-2-ylamine following General Procedure H.

Sources & evidence

ORD record
ord-b13200f8f22648b181dd1e08961c1cf7
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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