3-(Chloromethyl)-1,2,4-oxadiazole → HCID 58530637, compound

HRID 2401002Notes

Reaction equation

HRID 2401002 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Cl[CH2:31][C:32]1[N:36]=[CH:35][O:34][N:33]=1>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:31][C:32]5[N:36]=[CH:35][O:34][N:33]=5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 27357653-(Chloromethyl)-1,2,4-oxadiazoleHCID 86659608HCID 86659608, compound

Product 1

HCID 58530637HCID 58530637, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(1,2,4-oxadiazol-3-ylmethyl)-1,3-thiazolidine-2,4-dione was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and 3-(chloromethyl)-1,2,4-oxadiazole following General Procedure H.

Sources & evidence

ORD record
ord-690dbc2402cd436bb7c1166c335fa36c
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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