HRID2401009

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2770836

(2,4-dioxo-1,3-thiazolidin-3-yl)acetic acid

C5H5NO4S

结构：O=Cc1ccc2c(c1)c(-c1ccc(F)cc1)nn2Cc1ccc(Cl)cc1C(F)(F)F

HCID86659710

未命名化合物

PRODUCTS

生成物

$结构：O=C(O)CN1C(=O)S/C(=C\c2ccc3c(c2)c(-c2ccc(F)cc2)nn3Cc2ccc(Cl)cc2C(F)(F)F)C1=O$

HCID58530686

未命名化合物

PROCEDURE

实验过程

[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-3-(4-fluorophenyl)-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid was prepared from 1-(4-chloro-2-trifluoromethylbenzyl)-3-(4-fluorophenyl)-1H-indazole-5-carbaldehyde and (2,4-dioxothiazolidin-3-yl)acetic acid following General Procedure F.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-715284b356914ce3b5747d6e7de83fde
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08796256B2
来源说明: uspto-grants-2014_08

反应 SMILES

[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[O:31]=[C:32]1[N:36]([CH2:37][C:38]([OH:40])=[O:39])[C:35](=[O:41])[CH2:34][S:33]1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:34]4/[C:35](=[O:41])[N:36]([CH2:37][C:38]([OH:40])=[O:39])[C:32](=[O:31])[S:33]/4)=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)=[N:8]2)=[C:4]([C:27]([F:29])([F:30])[F:28])[CH:3]=1