1-Pyrrolidinesulfonyl chloride → HCID 58530944, compound

HRID 2401012Notes

Reaction equation

HRID 2401012 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:29])[N:19]([CH2:23][C:24]5[NH:25][CH:26]=[CH:27][N:28]=5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:32]([F:35])([F:34])[F:33])[CH:3]=1.[N:36]1([S:41](Cl)(=[O:43])=[O:42])[CH2:40][CH2:39][CH2:38][CH2:37]1>>[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:29])[N:19]([CH2:23][C:24]5[N:25]([S:41]([N:36]6[CH2:40][CH2:39][CH2:38][CH2:37]6)(=[O:43])=[O:42])[CH:26]=[CH:27][N:28]=5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:32]([F:35])([F:34])[F:33])[CH:3]=1

Participants

3

Reactant 2

HCID 64839021-Pyrrolidinesulfonyl chlorideHCID 58530691HCID 58530691, compound

Product 1

HCID 58530944HCID 58530944, compound

Procedure

(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{[1-(pyrrolidin-1-ylsulfonyl)-1H-imidazol-2-yl]methyl}-1,3-thiazolidine-2,4-dione was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(1H-imidazol-2-ylmethyl)-1,3-thiazolidine-2,4-dione (from Example 403) and 1-pyrrolidinesulfonyl chloride following General Procedure U.

Sources & evidence

ORD record
ord-89ba1a41a21a4e10b1943a5774e753e4
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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