Trifluoromethanesulfonyl chloride → HCID 58530628, compound

HRID 2401014Notes

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][N:8]2[C:12](=[O:13])/[C:11](=[CH:14]/[C:15]3[CH:16]=[C:17]4[C:21](=[CH:22][CH:23]=3)[N:20]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=3[C:32]([F:35])([F:34])[F:33])[N:19]=[CH:18]4)/[S:10][C:9]2=[O:36])[N:6]=1.[F:37][C:38]([F:44])([F:43])[S:39](Cl)(=[O:41])=[O:40]>>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][N:20]2[C:21]3[C:17](=[CH:16][C:15](/[CH:14]=[C:11]4/[C:12](=[O:13])[N:8]([CH2:7][C:5]5[N:6]=[C:2]([NH:1][S:39]([C:38]([F:44])([F:43])[F:37])(=[O:41])=[O:40])[S:3][CH:4]=5)[C:9](=[O:36])[S:10]/4)=[CH:23][CH:22]=3)[CH:18]=[N:19]2)=[C:26]([C:32]([F:35])([F:34])[F:33])[CH:27]=1

Participants

Reactant 2

HCID 79000Trifluoromethanesulfonyl chloride

HCID 58530403HCID 58530403, compound

Product 1

HCID 58530628HCID 58530628, compound

Procedure

N-(4-{[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}-1,3-thiazol-2-yl)-1,1,1-trifluoromethanesulfonamide was prepared from (5Z)-3-[(2-amino-1,3-thiazol-4-yl)methyl]-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (from Example 400) and trifluoromethanesulfonyl chloride following General Procedure U.

Sources & evidence

ORD record: ord-1fb5723352454a6cb951d0475d079612
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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