tert-butyl 1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylate → HCID 86659711, compound

HRID 2401015Notes

Reaction equation

HRID 2401015 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23][C:24]([OH:26])=O)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:33])([F:32])[F:31])[CH:3]=1.[C:34]([O:38][C:39]([N:41]1[CH2:45][CH2:44][NH:43][S:42]1(=[O:47])=[O:46])=[O:40])([CH3:37])([CH3:36])[CH3:35]>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:27])[N:19]([CH2:23][C:24]([N:43]5[S:42](=[O:47])(=[O:46])[N:41]([C:39]([O:38][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:40])[CH2:45][CH2:44]5)=[O:26])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:30]([F:31])([F:33])[F:32])[CH:3]=1

Participants

3

Reactant 2

HCID 15473621tert-butyl 1,1-dioxo-1,2,5-thiadiazolidine-2-carboxylateHCID 58530433HCID 58530433, compound

Product 1

HCID 86659711HCID 86659711, compound

Procedure

tert-Butyl 5-{[(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetyl}-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid (from Example 4) and 1,1-dioxo-1λ6-[1,2,5]thiadiazolidine-2-carboxylic acid tert-butyl ester following General Procedure C.

Sources & evidence

ORD record
ord-11b8fe071481485287561c6a49198040
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

Loading…