3,5-Dimethylisoxazole-4-sulfonyl chloride → HCID 58530784, compound

HRID 2401019Notes

Reaction equation

HRID 2401019 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[C:28]([F:31])([F:30])[F:29])[N:15]=[CH:14]3)/[S:6][C:5]1=[O:32].[CH3:33][C:34]1[C:38]([S:39](Cl)(=[O:41])=[O:40])=[C:37]([CH3:43])[O:36][N:35]=1>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][N:16]2[C:17]3[C:13](=[CH:12][C:11](/[CH:10]=[C:7]4/[C:8](=[O:9])[N:4]([CH2:3][CH2:2][NH:1][S:39]([C:38]5[C:34]([CH3:33])=[N:35][O:36][C:37]=5[CH3:43])(=[O:41])=[O:40])[C:5](=[O:32])[S:6]/4)=[CH:19][CH:18]=3)[CH:14]=[N:15]2)=[C:22]([C:28]([F:30])([F:29])[F:31])[CH:23]=1

Participants

3

Reactant 2

HCID 27363193,5-Dimethylisoxazole-4-sulfonyl chlorideHCID 58530605HCID 58530605, compound

Product 1

HCID 58530784HCID 58530784, compound

Procedure

N-{2-[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}-3,5-dimethylisoxazole-4-sulfonamide was prepared from 3-(2-aminoethyl)-(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (from Example 49) and 3,5-dimethylisoxazole-4-sulfonyl chloride following General Procedure U.

Sources & evidence

ORD record
ord-ee6e633d49954a69a8e6cf745f9d22dc
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

Loading…