2-Acetamido-4-methylthiazole-5-sulfonyl chloride → HCID 58530719, compound

HRID 2401020Notes

Reaction equation

HRID 2401020 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[C:28]([F:31])([F:30])[F:29])[N:15]=[CH:14]3)/[S:6][C:5]1=[O:32].[C:33]([NH:36][C:37]1[S:38][C:39]([S:43](Cl)(=[O:45])=[O:44])=[C:40]([CH3:42])[N:41]=1)(=[O:35])[CH3:34]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][N:16]2[C:17]3[C:13](=[CH:12][C:11](/[CH:10]=[C:7]4/[C:8](=[O:9])[N:4]([CH2:3][CH2:2][NH:1][S:43]([C:39]5[S:38][C:37]([NH:36][C:33](=[O:35])[CH3:34])=[N:41][C:40]=5[CH3:42])(=[O:44])=[O:45])[C:5](=[O:32])[S:6]/4)=[CH:19][CH:18]=3)[CH:14]=[N:15]2)=[C:22]([C:28]([F:30])([F:29])[F:31])[CH:23]=1

Participants

3

Reactant 2

HCID 969512-Acetamido-4-methylthiazole-5-sulfonyl chlorideHCID 58530605HCID 58530605, compound

Product 1

HCID 58530719HCID 58530719, compound

Procedure

N-[5-({2-[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl}sulfamoyl)-4-methyl-1,3-thiazol-2-yl]acetamide was prepared from 3-(2-aminoethyl)-(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione (from Example 49) and 2-acetamido-4-methyl-5-thiazolesulfonyl chloride following General Procedure U.

Sources & evidence

ORD record
ord-e65da4e0729145ffaf2486678f07074d
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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