4-Carboxyphenylboronic Acid → HCID 57444248, compound

HRID 2401026Notes

Reaction equation

HRID 2401026 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17](Cl)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[C:19]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)([OH:21])=[O:20]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:25]2[CH:26]=[CH:27][C:22]([C:19]([OH:21])=[O:20])=[CH:23][CH:24]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 3121834-Carboxyphenylboronic AcidHCID 57444247HCID 57444247, compound

Product 1

HCID 57444248HCID 57444248, compoundYield 83%

Procedure

Following the general method as outlined for Intermediate 4, starting from 2-chloro-N-(3-chloropyrazin-2-yl)benzenesulfonamide and 4-carboxybenzene boronic acid, the title compound was isolated, after evaporation and recrystallization, as a yellowish solid in 83% yield (96% purity by HPLC).

Sources & evidence

ORD record
ord-907fdf21cabb41788fc6bfb6e2bc24e6
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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