HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Carboxyphenylboronic Acid → 4-(3-{[(2-Trifluoromethylphenyl)sulfonyl]amino}pyrazin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Carboxyphenylboronic Acid | HCID 312183 | — |
| Reactant | N-(3-chloropyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide | HCID 57586069 | — |
| Product | 4-(3-{[(2-Trifluoromethylphenyl)sulfonyl]amino}pyrazin-2-yl)benzoic acid | HCID 57444249 | 80% |
Reaction Steps
Following the general method as outlined for Intermediate 4, starting from N-(3-chloropyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide and 4-carboxybenzene boronic acid, the title compound was isolated, after evaporation and recrystallization, as a yellowish solid in 80% yield (98% purity by HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796280B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-913bb5006feb4f2aa36e9793e4e533c7 |
| Source note | uspto-grants-2014_08 |