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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2401029Generated: October 26, 2026

Thionyl Chloride → N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide

https://huagongshe.com/reaction/2401029

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant2-trifluoromethyl-N-{3-[4-(hydroxymethyl)phenyl]pyrazin-2-yl}benzene sulfonamideHCID 57586071—
ProductN-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamideHCID 5744425096%

Reaction Steps

Following the general method as outlined for Intermediate 8, starting from 2-trifluoromethyl-N-{3-[4-(hydroxymethyl)phenyl]pyrazin-2-yl}benzene sulfonamide and thionyl chloride, the title compound was isolated, after evaporation and recrystallization, as a white solid in 96% yield (97% purity by HPLC).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08796280B2
Source datasetuspto-grants-2014_08
ORD IDord-6fa944b9339a460593df8922a28d9e07
Source noteuspto-grants-2014_08