Trifluoroacetic acid → HCID 57586068, compound

Participants

Reaction Steps

tert-butyl 4-[3-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)pyrazin-2-yl]piperazine-1-carboxylate (1.46 g, 3 mmol) was dissolved in dichloromethane (50 mL) and trifluoroacetic acid (4.5 g, 40 mmol) was added at 0° C. The reaction mixture was stirred for 2 h. The solvents were evaporated and the residue redissolved in dichloromethane (50 ml) and evaporated to dryness to give the expected product N-(3-piperazin-1-ylpyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide as a yellow solid (1.1 g, 95% yield, 95% purity by HPLC).

Provenance & Evidence