5,6,7,8-Tetrahydro-2-naphthol → HCID 11960062, compound

HRID 2401040Notes

Reaction equation

HRID 2401040 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[OH:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[CH2:33][CH2:32][CH2:31][CH2:30]2>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:19]=[CH:20][C:21]([CH2:24][O:26][C:27]3[CH:36]=[CH:35][C:34]4[CH2:33][CH2:32][CH2:31][CH2:30][C:29]=4[CH:28]=3)=[CH:22][CH:23]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 143055,6,7,8-Tetrahydro-2-naphtholHCID 574442542-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide2×

Product 1

HCID 11960062HCID 11960062, compoundYield 69%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 2-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide (Intermediate 8), and 6-hydroxy-1,2,3,4-tetrahydronaphtalene, the title compound was isolated as a yellow solid in 69% yield (99% purity by HPLC).

Sources & evidence

ORD record
ord-bf6f6a0ec23a45ddbe32bdce1f2f7053
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

Loading…