1,3-Benzodioxol-5-amine → N-(3-{4-[(1,3-benzodioxol-5-ylamino)methyl]phenyl}pyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	1,3-Benzodioxol-5-amine	HCID 84310	—
Reactant	N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide	HCID 57444250	—
Product	N-(3-{4-[(1,3-benzodioxol-5-ylamino)methyl]phenyl}pyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide	HCID 11960144	69%

Reaction Steps

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and 3,4-(methylenedioxy)aniline, the title compound was isolated as a yellow solid in 69% yield (96% purity by HPLC).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796280B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-3c0a2b57cde34a78b3a6f8372129d950
Source note	uspto-grants-2014_08