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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2401043Generated: October 26, 2026

3-Methoxybenzyl alcohol → N-[3-(4-{[(3-methoxybenzyl)oxy]methyl}phenyl)pyrazin-2-yl]-2-(trifluoromethyl)benzenesulfonamide

https://huagongshe.com/reaction/2401043

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methoxybenzyl alcoholHCID 81437—
ReactantN-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamideHCID 57444250—
ProductN-[3-(4-{[(3-methoxybenzyl)oxy]methyl}phenyl)pyrazin-2-yl]-2-(trifluoromethyl)benzenesulfonamideHCID 1196014564%

Reaction Steps

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and 3-anisyl alcohol, the title compound was isolated as a yellow solid in 64% yield (92% purity by HPLC).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08796280B2
Source datasetuspto-grants-2014_08
ORD IDord-a6164c2d89b0482c9808fd071f1a66d5
Source noteuspto-grants-2014_08