n-Methyl-4-(trifluoromethoxy)aniline → HCID 11960146, compound

HRID 2401044Notes

Reaction equation

HRID 2401044 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=3)=[N:16][CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:26][NH:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][C:12]2[C:17]([C:18]3[CH:19]=[CH:20][C:21]([CH2:24][N:27]([CH3:26])[C:28]4[CH:33]=[CH:32][C:31]([O:34][C:35]([F:36])([F:37])[F:38])=[CH:30][CH:29]=4)=[CH:22][CH:23]=3)=[N:16][CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 737351n-Methyl-4-(trifluoromethoxy)anilineHCID 67411829HCID 67411829, compound

Product 1

HCID 11960146HCID 11960146, compoundYield 69%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 3-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide, and N-methyl-4-(trifluoromethoxy)aniline, the title compound was isolated as a yellow solid in 69% yield (94% purity by HPLC).

Sources & evidence

ORD record
ord-06c0e65be82943f4b7d22d11fda40765
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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