4-Chloro-N-methylbenzenamine → HCID 11960147, compound

HRID 2401045Notes

Reaction equation

HRID 2401045 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[CH3:24][NH:25][C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=1>>[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([N:25]([CH2:2][C:3]2[CH:4]=[CH:5][C:6]([C:9]3[C:10]([NH:15][S:16]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)(=[O:17])=[O:18])=[N:11][CH:12]=[CH:13][N:14]=3)=[CH:7][CH:8]=2)[CH3:24])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 702724-Chloro-N-methylbenzenamineHCID 69021452HCID 69021452, compound

Product 1

HCID 11960147HCID 11960147, compoundYield 69%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}thiophene-2-sulfonamide, and N-methyl-4-chloro aniline, the title compound was isolated as a yellow solid in 69% yield (94% purity by HPLC).

Sources & evidence

ORD record
ord-9052ad6b2bed444da1edaa65f2169785
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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