n-Methyl-4-(trifluoromethoxy)aniline → HCID 11960234, compound

HRID 2401047Notes

Reaction equation

HRID 2401047 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[CH3:26][NH:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][C:35]([F:38])([F:37])[F:36])=[CH:30][CH:29]=1>>[CH3:25][C:22]1[CH:21]=[CH:20][C:19]([S:16]([NH:15][C:10]2[C:9]([C:6]3[CH:5]=[CH:4][C:3]([CH2:2][N:27]([CH3:26])[C:28]4[CH:33]=[CH:32][C:31]([O:34][C:35]([F:36])([F:37])[F:38])=[CH:30][CH:29]=4)=[CH:8][CH:7]=3)=[N:14][CH:13]=[CH:12][N:11]=2)(=[O:17])=[O:18])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 737351n-Methyl-4-(trifluoromethoxy)anilineHCID 67412869HCID 67412869, compound

Product 1

HCID 11960234HCID 11960234, compoundYield 69%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-4-methylbenzenesulfonamide, and N-methyl-4-(trifluoromethoxy)aniline, the title compound was isolated as a yellow solid in 69% yield (94% purity by HPLC).

Sources & evidence

ORD record
ord-3d764d2ee1d14fcebd5b353447661a6b
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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