n-Methyl-4-(trifluoromethoxy)aniline → HCID 11960236, compound

HRID 2401049Notes

Reaction equation

HRID 2401049 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[CH3:27][NH:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=1>>[C:25]([C:22]1[CH:21]=[CH:20][C:19]([S:16]([NH:15][C:10]2[C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][N:28]([CH3:27])[C:29]4[CH:34]=[CH:33][C:32]([O:35][C:36]([F:37])([F:38])[F:39])=[CH:31][CH:30]=4)=[CH:4][CH:5]=3)=[N:14][CH:13]=[CH:12][N:11]=2)(=[O:17])=[O:18])=[CH:24][CH:23]=1)#[N:26]

Participants

3

Reactant 2

HCID 737351n-Methyl-4-(trifluoromethoxy)anilineHCID 67412765HCID 67412765, compound

Product 1

HCID 11960236HCID 11960236, compoundYield 70%

Procedure

Following the general method as outlined in Example 1 (Method D), N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-4-cyanobenzenesulfonamide, and N-methyl-4-(trifluoromethoxy)aniline, the title compounds were isolated as a yellow solid in 70% yield (92% purity by HPLC).

Sources & evidence

ORD record
ord-ba12228937894525a8b7e58778c355c0
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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