HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → N-(3-{4-[(Methyl-phenyl-amino)-methyl]-phenyl}-pyrazin-2-yl)-2-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide | HCID 57444250 | — |
| Product | N-(3-{4-[(Methyl-phenyl-amino)-methyl]-phenyl}-pyrazin-2-yl)-2-trifluoromethyl-benzenesulfonamide | HCID 11960237 | 75% |
Reaction Steps
Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and N-methylaniline, the title compound was isolated as a yellow solid in 75% yield (99% purity by HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796280B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-142798d4e90949628be33ee012d4db24 |
| Source note | uspto-grants-2014_08 |