4-Methoxyphenol → HCID 11960455, compound

HRID 2401067Notes

Reaction equation

HRID 2401067 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[OH:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1>>[CH3:37][O:36][C:33]1[CH:34]=[CH:35][C:30]([O:29][CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[C:10]([NH:15][S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=3)=[CH:5][CH:4]=2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 57444250N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide2×

Product 1

HCID 11960455HCID 11960455, compoundYield 48%

Procedure

Following the general method as outlined in Example 1 (Method 8), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and 4-hydroxyanisole, the title compound was isolated as a yellow solid in 48% yield (91% purity by HPLC).

Sources & evidence

ORD record
ord-ce673bf3aa104ff5a67749b15f0efdfd
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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