2,4-Dichloro-N-methylaniline → HCID 11960456, compound

HRID 2401070Notes

Reaction equation

HRID 2401070 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[Cl:29][C:30]1[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:31]=1[NH:32][CH3:33]>>[Cl:29][C:30]1[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:31]=1[N:32]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:27])([F:26])[F:28])(=[O:17])=[O:18])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1)[CH3:33]

Participants

3

Reactant 2

HCID 28009352,4-Dichloro-N-methylanilineHCID 57444250N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide2×

Product 1

HCID 11960456HCID 11960456, compoundYield 69%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and 2,4-dichloro-N-methylaniline, the title compound was isolated as a yellow solid in 69% yield (96% purity by HPLC).

Sources & evidence

ORD record
ord-00a27a9f5ddd4f3a8d21d9fb326b5987
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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