5-Fluoroindole → HCID 11960562, compound

HRID 2401074Notes

Reaction equation

HRID 2401074 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[F:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][CH:31]=[CH:30]2>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:19]=[CH:20][C:21]([CH2:24][N:32]3[C:33]4[C:29](=[CH:28][C:27]([F:26])=[CH:35][CH:34]=4)[CH:30]=[CH:31]3)=[CH:22][CH:23]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 678615-FluoroindoleHCID 574442542-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide2×

Product 1

HCID 11960562HCID 11960562, compoundYield 72%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 2-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide (Intermediate 8), and 5-fluoroindole, the title compound was isolated as a yellow solid in 72% yield (96% purity by HPLC).

Sources & evidence

ORD record
ord-b0178177908c444a999c0ba2368438fe
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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