2-(Ethylamino)pyridine → HCID 11960662, compound

HRID 2401077Notes

Reaction equation

HRID 2401077 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[CH2:26]([NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1)[CH3:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][N:28]([CH2:26][CH3:27])[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 118047452-(Ethylamino)pyridineHCID 574442542-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide2×

Product 1

HCID 11960662HCID 11960662, compoundYield 64%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 2-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide (Intermediate 8), and 2-(ethylamino)-pyridine, the title compound was isolated as a yellow solid in 64% yield (96% purity by HPLC).

Sources & evidence

ORD record
ord-704db9177ed64128a3d5665675550628
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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