5-Chloro-2-methylindole → HCID 11960663, compound

HRID 2401078Notes

Reaction equation

HRID 2401078 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[CH3:29][C:30]1[NH:31][C:32]2[C:37]([CH:38]=1)=[CH:36][C:35]([Cl:39])=[CH:34][CH:33]=2>>[Cl:39][C:35]1[CH:36]=[C:37]2[C:32](=[CH:33][CH:34]=1)[N:31]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]3[C:10]([NH:15][S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:27])([F:26])[F:28])(=[O:17])=[O:18])=[N:11][CH:12]=[CH:13][N:14]=3)=[CH:5][CH:4]=1)[C:30]([CH3:29])=[CH:38]2

Participants

3

Reactant 2

HCID 706365-Chloro-2-methylindoleHCID 57444250N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide2×

Product 1

HCID 11960663HCID 11960663, compoundYield 71%

Procedure

Following the general method as outlined in Example 1 (Method A), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide (Intermediate 9), and 2-methyl-5-chloroindole, the title compound was isolated as a yellow solid in 71% yield (95% purity by HPLC).

Sources & evidence

ORD record
ord-82fdcf20fc1b46289b2d6d038d785298
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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