HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Oxo-propyl)tetrahydro-pyran-4-carboxylic acid methyl ester → 4-{3-[2-Methyl-6-((2S,3'R)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-ylamino]-propyl}-tetrahydro-pyran-4-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Oxo-propyl)tetrahydro-pyran-4-carboxylic acid methyl ester | HCID 58468057 | — |
| Reactant | 2-methyl-6-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-amine | HCID 67480461 | — |
| Product | 4-{3-[2-Methyl-6-((2S,3'R)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-ylamino]-propyl}-tetrahydro-pyran-4-carboxylic acid methyl ester | HCID 71280401 | — |
Reaction Steps
The title compound was synthesized in essentially the same manner using the procedures as set forth in Step 1 of Example 1, by condensing 4-(3-oxo-propyl)-tetrahydro-pyran-4-carboxylic acid methyl ester (44 mg, 0.22 mmol) and 2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-ylamine to obtain 84 mg of a crude solid, which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796278B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-c93cee10b2b04ba98cd14b944be5c3d5 |
| Source note | uspto-grants-2014_08 |