HCID 58478452, compound → HCID 71280540, compound

HRID 2401123Notes

Reaction equation

HRID 2401123 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH2:19][CH2:20][CH:21]=O)[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:23][C:24]1[C:29]([NH2:30])=[CH:28][CH:27]=[C:26]([N:31]2[CH2:35][CH2:34][C@@H:33]([N:36]3[CH2:40][CH2:39][CH2:38][C@@H:37]3[CH3:41])[CH2:32]2)[N:25]=1>>[CH2:1]([O:3][C:4]([C:6]1([CH2:19][CH2:20][CH2:21][NH:30][C:29]2[C:24]([CH3:23])=[N:25][C:26]([N:31]3[CH2:35][CH2:34][C@@H:33]([N:36]4[CH2:40][CH2:39][CH2:38][C@@H:37]4[CH3:41])[CH2:32]3)=[CH:27][CH:28]=2)[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 58478452HCID 58478452, compoundHCID 674804612-methyl-6-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-amine

Product 1

HCID 71280540HCID 71280540, compound

Procedure

The title compound was synthesized in essentially the same manner using the procedures as set forth in Step 1 of Example 1, by condensing 4-(3-oxo-propyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (69 mg, 0.22 mmol) and 2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-ylamine to obtain 113 mg of a crude solid, which was used without purification.

Sources & evidence

ORD record
ord-cd0e6ff8251847d79754d7daf0937ce8
Source dataset
uspto-grants-2014_08
Patent number
US08796278B2

Reaction notes

Loading…