2-methyl-6-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-amine → HCID 71280376, compound
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH2:30][CH:31]=O)[CH2:11][CH2:10][CH:9]([O:12][Si:13]([C:26]([CH3:29])([CH3:28])[CH3:27])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:33][C:34]1[C:39]([NH2:40])=[CH:38][CH:37]=[C:36]([N:41]2[CH2:45][CH2:44][C@@H:43]([N:46]3[CH2:50][CH2:49][CH2:48][C@@H:47]3[CH3:51])[CH2:42]2)[N:35]=1>>[CH2:1]([O:3][C:4]([C:6]1([CH2:30][CH2:31][NH:40][C:39]2[C:34]([CH3:33])=[N:35][C:36]([N:41]3[CH2:45][CH2:44][C@@H:43]([N:46]4[CH2:50][CH2:49][CH2:48][C@@H:47]4[CH3:51])[CH2:42]3)=[CH:37][CH:38]=2)[CH2:7][CH2:8][CH:9]([O:12][Si:13]([C:26]([CH3:29])([CH3:27])[CH3:28])([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]Participants
3
Procedure
The title compound was synthesized in essentially the same manner using the procedures as set forth in Step 1 of Example 1, by condensing 4-(tert-butyl-diphenyl-silanyloxy)-1-(2-oxo-ethyl)-cyclohexanecarboxylic acid ethyl ester (100 mg, 0.22 mmol) and 2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-ylamine to obtain 132 mg of a crude solid, which was used in the next reaction without further purification.
Sources & evidence
- ORD record
- ord-6f9adcbebd55454384914d9ef069f20a
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08796278B2
Reaction notes
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